منابع مشابه
Treatment algorithms in stage IV melanoma.
The molecular classification of melanoma and the advent of new drugs are changing the paradigm of therapy for advanced melanoma. A review of the recent key studies was performed, followed by a discussion in an expert forum. The aim of this review was to generate a therapeutic algorithm for stage IV melanoma. Tumor genotyping for BRAF and/or KIT should be performed before selection of therapy. F...
متن کاملComplete metastasectomy in patients with stage IV metastatic melanoma.
Patients with stage IV melanoma have traditionally been managed with various systemic treatments; however, overall survival with this approach has been disappointing. Findings of many retrospective, single-institution, and multicentre studies suggest that participants treated with complete metastasectomy for stage IV metastases have enhanced overall 5-year survival. Complete surgical resection ...
متن کاملResults of systemic treatment of cutaneous melanoma in inoperable stage III and IV
AIM OF THE STUDY The incidence of melanoma is increasing rapidly worldwide. Metastatic melanoma is still an incurable disease, although an era of new drugs is approaching. Current methods to predict outcomes in patients with advanced, metastatic melanoma are limited. A retrospective analysis of a contemporary large group of advanced melanomas was performed to determine clinical prognostic facto...
متن کاملWhen to perform surgery in stage IV melanoma patients?
Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com nal, adrenal and splenic metastases are known examples in melanoma patients which can lead to signs of obstruction, bleeding and/or pain and good palliation has been described in these patients [4–6]. Also patients with metastases that may cause significant symptoms before the patient die...
متن کاملContemporary surgical treatment of advanced-stage melanoma.
HYPOTHESIS The clinical treatment of patients with stage IV melanoma according to criteria of the American Joint Committee on Cancer (AJCC) is controversial because the 5-year survival rate is approximately 5%. Specific clinicopathologic factors are predictive of survival following curative surgery. DESIGN Cohort analysis of 1574 successive patients undergoing surgical resection of metastatic...
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ژورنال
عنوان ژورنال: American Journal of Therapeutics
سال: 2015
ISSN: 1075-2765
DOI: 10.1097/mjt.0b013e31829e885c